Respected London criminal psychiatrist Dr. Michael Glass (David Morrissey) is brought in by a Scotland Yard detective (David Thewlis) to perform a psychiatric evaluation of a beautiful and captivating woman who has been linked to the mysterious death of a famous athlete. The woman in question is Catherine Tramell (Sharon Stone), a best-selling American crime novelist whose grisly fictional crimes take place in real life with alarming frequency. Glass is intrigued by the author, and against the advice of his mentor, Dr. Milena Gardosh (Charlotte Rampling), he is quickly sucked into her web of lies and seduction. Professional boundaries are obliterated as she uncovers his basic instincts. A deadly battle of wits ensues, climaxing as Glass faces a choice that will change both of their lives forever.